Erythropoletin
A hormone produced naturally by the kidneys that stimulates the production of red blood cells by the bone marrow. A form of erythropoietin (epoetin) produced by genetic engineering is used to treat anaemia associated with chronic kidney failure.
Epoetin is also used in patients undergoing chemotherapy with platinum-containing drugs in order to shorten the period of anaemia. It is given by subcutaneous, intravenous, or intramuscular injection and is available on prescription only.
Side effects: include raised blood pressure, headache, thrombosis, influenza-like symptoms, epileptic seizures, and rashes.
Precautions: erythropoietin should not be given to people with untreated high blood pressure. It should be used with caution in those with vascular disease, cancer, a history of epilepsy, or liver disease and in pregnant or breastfeeding women.
Interactions with other drugs: ACE inhibitors: there is an increased risk of high concentrations of potassium in the plasma.
Proprietary preparations: Eprex (epoetin alfa); Neorecormon (epoetin beta).