Diflucan (Fluconazole)
Proprietary preparations: Floxapen; Fluclomix; Galfloxin; Ladropen;
Zoxin; Flu-Amp (see COFLUAMPICIL); Magnapen (see COFLUAMPICIL).
fluconazole A triazole antifungal drug used for the treatment of
many fungal infections, especially candidiasis (of the mouth, vagina, or throat), athlete’s foot, and cryptococcal meningitis (a form of meningitis that can occur as an opportunistic infection in AIDS patients). Available on prescription, fluconazole can be taken orally, as capsules or a suspension, or it can be given by intravenous infusion. Capsules for treating vaginal candidiasis (maximum dose 150 mg) can be bought from pharmacies without a prescription.
Side effects:
include abdominal discomfort, diarrhoea, and flatulence.
Rarely, allergic reactions may occur; if a rash develops, the treatment
should be stopped and a doctor consulted.
Precautions:
fluconazole should be used with caution by people with
impaired kidney function and by women who are pregnant or
breastfeeding.
Interactions with other drugs:
Antacids: reduce the absorption of fluconazole.
Anticoagulants: the anticoagulant effects of warfarin and nicoumalone
Antidiabetic drugs: the plasma concentrations of the sulph – is are increased.
Astemizole: should not be taken with fluconazole because of the risk of abnormal heart rhythms.
Cisapride: should not be taken with fluconazole.
Hydrochlorothiazide: increases the plasma concentration of fluconazole.
Phenytoin: its effect is enhanced.
Rifampicin: reduces the plasma concentration of fluconazole.
Terfenadine: should not be taken with fluconazole because of the risk c: abnormal heart rhythms.
Theophylline: fluconazole increases the plasma concentration of theophylline, which may increase its side effects in patients receivinz high doses of this drug.
Proprietary preparations:
Diflucan; Diflucan One (available without a prescription).